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Cardarine (GW501516) acts as a PPAR-ß modulator. GW 501516 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue, and GW-501516 has been demonstrated to reverse metabolic abnormalities in obese users with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation. GW1516 increases muscle gene expression, especially genes involved in preferential lipid utilization. This shift changes the body’s metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing fat loss effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. GW1516 significantly increases endurance which improved glucose tolerance and reduced fat mass accumulation even in a very high fat diet, suggesting that GW1516 may have a protective effect against obesity.
S4 (Andarine) or Acetamidoxolutamide, is a G-Gear (Selective Androgen Receptor Modulator). Developed as drug to reduce muscle wasting – G-Gear's are a versatile compound that can help gain strength, muscle and lose fat. Andarine’s exceptional ability to help oxidize fat and keep the body from going catabolic while on a low calorie diet is its specialty. It will provide a hard, dry, lean look and increase vascularity. It provides notable strength and endurance even while in caloric deficit, and, at higher doses, it can even add hard muscle to your frame.
SR-9009, stenabolic, works by stimulating the Rev-Erb protein which has an effect on circadian rhythms, fat-storing cells as well as glucose and lipid metabolism. By activating Rev-erb protein it increases cell production through mitochondria giving the muscle increased energy as well as giving the metabolism enhanced speed. Thus increasing the mitochondria in the muscle will result in strength gain as well as drastic energy increase to go along with strides in endurance. Using SR has been known to show up to 50% increases in complete all around endurance due to increases in mitochondria count. The biggest component that Stenabolic has is that it boosts metabolic activity and is known to mimic aerobic exercise without having to actually exercise hence being called “exercise in a bottle”. Research shows SR9009 uses body fat that is stored and uses it as energy for exercise. Due to the many effects it has it is a lean muscle gainer and can aid in strength gains while also burning fat.
Laxogenin (5-Alpha-Hydroxy-Laxogenin) is a naturally occurring steroidal sapogenin, extracted from Smilax Sieboldii, a plant related to asparagus. Laxogenin is a member of a group of plant-based steroids, known as brassinosteroids, which are readily found in small quantities in the pollen, seeds, and leaves of a number of plants and foods. The compound is similar in structure to ecdysterone, another widely used plant-derived anabolic agent.